A 20aa peptide within the extracellular, N-terminal domain, and a 20-aa peptide mapping at the cytoplasmic, C-terminal domain of human NMUR1. The neuromedins (Nm) are a family of bioactive peptides best known for their roles in smooth muscle contraction. Nm family of bioactive peptides include: Bombesin-like (NmB, NmC), kassinin-like (NmL and NmK or neurokinins A and B), neurotensin-like (NmN), and neuromedin U (NmU, for its ability to stimulate uterine muscle contraction). Besides its roles in smooth muscle contraction (human ileum, urinary bladder, rat stomach etc), NmU has also been implicated in hypertension, blood flow in intestine, and neurotransmission. Recently two structurally related, orphan G-protein coupled receptors, termed NMUR1 (GPCR66/FM-3/SNORF62) and NMUR2 (TGR-1/FM-4/SNORF72), have been identified as cognate receptors of NmU. NMU receptors display a typical 7 TM domains with extracellular N-terminus and intracellular C-terminus. Applications: Suitable for use in ELISA or antibody blocking. Not suitable for Western Blot. Other aplications not tested. Recommended Dilution: ELISA: 5-10ug per 1ug of affinity pure IgG or 1ul antiserum. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Purity:
Highly purified
Form:
Supplied as a liquid in PBS, pH 7.2
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