| Control Peptide for O3001-10 (antiserum) and O3001 and O3001-09 (affinity purified) A 12aa Peptide near the cytoplasmic C-terminus of rat OATP2 Mammalian kidney and liver are critical in maintaining physiological ionic environment. Kidney specializes in removing toxins, drugs, and other organic anions from the blood by a process called renal secretion. Besides kidney, anionic substrates are also transported in other organs, e.g., choroid plexus, eye, airway, and placenta. Several multispecific OATs (OAT1-3, OAT-K1 and OATK2) and OATPs (organic anion transporting polypeptides, oatp1-3, LST-1, and PGT), have been cloned and characterized from various tissues. OATPs family of proteins share significant sequence homology, and general secondary protein structure (up to 12 transmembrane domains with cytoplasmic N and C-terminus). Oatp2 (also called OATP-B1, 661 aa, 12 TM), cloned from rat brain, shares significant homology with rat oatp1 and OAT-K1 (77%) and human OATP (73%). It is highly expressed in brain, liver, and kidney but not in heart, spleen, lung, muscle, and testes. Oatp2 mediates uptake of taurocholate, estrogen conjugates, and cardiac glycosides ouabain. Unlike other oatps, oatp2 also transported digioxin. |
