Omi, HtrA2 (S306A), Recombinant, Human, aa134-458, His-Tag (HtrA serine peptidase 2)
Catalog Number:
USB-O6350-10
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| Article Name: | Omi, HtrA2 (S306A), Recombinant, Human, aa134-458, His-Tag (HtrA serine peptidase 2) |
| Biozol Catalog Number: | USB-O6350-10 |
| Supplier Catalog Number: | O6350-10 |
| Alternative Catalog Number: | USB-O6350-10-100,USB-O6350-10-500 |
| Manufacturer: | US Biological |
| Category: | Molekularbiologie |
| HtrA2 also called Omi is a mammalian serine protease at high temperatures and has a chaperone activity at low temperature. The full-length HtrA2 is synthesized as a precursor protein and then targeted to the mitochondria where it is matured by the removal of N-terminal 133 residues. Mature HtrA2 consists of a putative transmembrane domain, an inhibitor of apoptosis protein (IAP)-binding motif, a single C-terminal PDZ domain that mediates protein-protein interactions. Recently, HtrA2 has known to contribute both to caspase-dependent and caspase-independent cell death. Recombinant protein corresponding to aa134-458 from human HtrA2, fused to His-Tag expressed in E. coli. Amino Acid Sequence: MAVPSPPPAS PPSQYNFIAD VVEKTAPAVV YIEILDRHPF LGREVPISNG SGFVVAADGL IVTNAHVVAD RRRVRVRLLS GDTYEAVVTA VDPVADIATL RIQTKEPLPT LPLGRSADVR QGEFVVAMGS PFALQNTITS GIVSSAQRPA RDLGLPQTNV EYIQTDAAID FGNAGGPLVN LDGEVIGVNT MKVTAGISFA IPSDRLREFL HRGEKKNSSS GISGSQRRYI GVMMLTLSPS ILAELQLREP SFPDVQHGVL IHKVILGSPA HRAGLRPGDV ILAIGEQMVQ NAEDVYEAVR TQSQLAVQIR RGRETLTLYV TPEVTEGSHH HHHH Enzyme Activity: Not determined. This product is recommended for use in applications that do not require a catalytically active form of the protein. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
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