Several peptides associated with feeding behavior have been reported recently. Orexins (Orexin-A and Orexin-B) are a family of hypothalamic neuropeptides selectively expressed in the hypothalamus. Orexin-A and Orexin-B are derived from the same precursor (Prepro-orexin) by proteolytic cleavage. Prepro-orexin is a 130aa long peptide with a putative 33aa secretory sequence, a hydrophobic core followed by residues with small polar side chains. The expression was detected in brain and to a small extent in testis. These neuropeptides bind and activate two closely related Orexin receptors- -G-protein coupled receptors (GPCRs) OX1R and OX2R. Source: Mouse/rat/human Orexin-A is a 33aa peptide. Full length Orexin-A peptide corresponding to aa1-33 (
Purity:
Purified by HPLC
Form:
Supplied as a lyophilized powder with no additives. Reconstitute with 1ml ddH2O and mix for 15 minutes at RT.
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