Organic Anion Transporter K1, Rat (OAT-K1) (Control Peptide)
Biozol Catalog Number:
USB-O7799-01B
Supplier Catalog Number:
O7799-01B
Alternative Catalog Number:
USB-O7799-01B-100
Manufacturer:
US Biological
Category:
Molekularbiologie
Application:
ELISA
A 14aa Peptide sequence near the cytoplasmic, C-terminus of rat OAT-K1. Mammalian kidney and liver are critical in maintaining physiological ionic environment. Kidney specializes in removing toxins, drugs, and other organic anions from the blood by a process called renal secretion. Besides kidney, anionic substrates are also transported in other organs, e.g., choroid plexus, eye, airway, and placenta. Several multispecific OATs (OAT1-3, OAT-K1 and OATK2) and OATPs (organic anion transporting polypeptides, oatp1-3), have been cloned and characterized from various tissues. OATPs family of proteins are very similar in sequence and secondary protein structure (up to 12 transmembrane domains with cytoplasmic N and C-terminus). A kidney-specific anion transporter termed OAT-K1 (rat 669 aa) has been cloned from rat kidney. OAT-K1 mRNA is specifically expressed in brush-borer membrane of the proximal straight tubules. Rat OAT-K1 (669 aa) shows 72% identity with rat liver oatp. It mediates basolateral uptake of anionic methotrexate but not PAH, taurocholate, and prostaglandin E2. OAT-K2 (498 aa), very similar to OAT-K1 (91% identity), has also been cloned from rat kidney. It also has 62-65% homology with oatp1-3 family of proteins. OAT-K2 is predominantly expressed in convoluted tubules, proximal straight tubules, and cortical collecting ducts. OAT-K2 mediates uptake of hydrophobic anions such as taurocholate, methotrexate, folate, and prostaglandin E2 suggesting that OAT-K2 participate in epithelial transport of hydrophobic anionic compound in the kidney.
Purity:
Highly purified
Form:
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
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