A four carbon dicarboxylic acid that is an intermediate in the citric acid cycle and glucogenesis. It has been shown to inhibit succinate dehydrogenase. Oxaloacetic acid, in the form of its conjugate base oxaloacetate, is a metabolic intermediate in many processes that occur in animals. It takes part in the: gluconeogenesis, urea cycle, glyoxylate cycle, amino acid synthesis, fatty acid synthesis and citric acid cycle. Gluconeogenesis[1] is a metabolic pathway consisting of a series of eleven enzyme-catalyzed reactions, resulting in the generation of glucose from non-carbohydrates substrates. The beginning of this process takes place in the mitochondrial matrix, where pyruvate molecules are found. A pyruvate molecule is carboxylated by a pyruvate carboxylase enzyme, activated by a molecule each of ATP and water. This reaction results in the formation of oxaloacetate. NADH reduces oxaloacetate to malate. This transformation is needed to transport the molecule out of the mitochondria. Once in the cytosol, malate is oxidized to oxaloacetate again using NAD+. Then oxaloacetate remains in the cytosol, where the rest of reactions will take place. Oxaloacetate is later decarboxylated and phosphorylated by phosphoenolpyruvate carboxykinase and becomes 2-phosphoenolpyruvate using a GTP as phosphate source. Glucose is obtained after further downstream processing.[1] Synonyms: Oxobutanedioic Acid, Oxalacetic Acid, 2-Ketosuccinic acid, 2-Oxobutanedioic acid, 2-Oxosuccinic Acid, Ketosuccinic Acid, NSC 284205, NSC 77688, OAA, Oxaloacetic Acid, Oxaloethanoic Acid, Oxosuccinic Acid, alpha-Ketosuccinic Acid CAS No: 328-42-7 Molecular Formula: C4H4O5 Molecular Weight: 132.07 Appearance: White to off-white powder Purity: 98% Infrared Spectrum: Conforms to structure Water (KF): 2% Storage and Stability: Store at 4C Stable for 12 months after receipt.
Molecular Weight:
132.07
CAS Number:
[328-42-7]
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