Plasminogen Activator Inhibitor Type 1, Human, active wild type (PAI-1) (Biotin)

Product Overview

• Article Name: Plasminogen Activator Inhibitor Type 1, Human, active wild type (PAI-1) (Biotin)
• Biozol Catalog Number: USB-P4256-29E
• Supplier Catalog Number: P4256-29E
• Alternative Catalog Number: USB-P4256-29E-500
• Manufacturer: US Biological
• Category: Molekularbiologie

Product Description

Plasminogen Activator Inhibitor 1 (PAI-1) is a glycoprotein found in plasma that is implicated in the processes of angiogenesis, hemostasis, tumor metastasis, fibrionlysis, ovulation, embryonic development and inflammation (1). The elevation of PAI-1 has shown to correlate with the prognosis of many cancers including breast cancer (2,3,4). PAI-1 is activated by the glycoprotein vitronectin. Vitronectin binds to PAI-1 and modulates fibrinolysis and cell migration (5). This binding has proven to be an important inhibitor of the activated form of protein C (APC) (6). Solubility: >2mg/ml and <5mg/ml Kinetic Data: Second order rate constants for inhibition of: uPA = 6.3 X 10e6 M -1s -1 tPA = 5.7 X 10e6 M -1s -1 Storage and Stability: May be stored at 4C for short-term only. For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 12 months.

Product Properties

• Molecular Weight: 43
• Purity: 98% by SDS PAGE 95 5% active by uPA titration
• Form: Supplied as a liquid in 0.05M sodium phosphate, 0.1M sodium chloride, 1mM EDTA, pH 6.6. Labeled with Biotin.