Plasminogen Activator Inhibitor Type 1, Human, mutant, active wild type (PAI-1)

Product Overview

• Article Name: Plasminogen Activator Inhibitor Type 1, Human, mutant, active wild type (PAI-1)
• Biozol Catalog Number: USB-P4256-29G
• Supplier Catalog Number: P4256-29G
• Alternative Catalog Number: USB-P4256-29G-500
• Manufacturer: US Biological
• Category: Molekularbiologie

Product Description

Plasminogen Activator Inhibitor 1 (PAI-1) is a glycoprotein found in plasma that is implicated in the processes of angiogenesis, hemostasis, tumor metastasis, fibrionlysis, ovulation, embryonic development and inflammation (1). The elevation of PAI-1 has shown to correlate with the prognosis of many cancers including breast cancer (2,3,4). PAI-1 is activated by the glycoprotein vitronectin. Vitronectin binds to PAI-1 and modulates fibrinolysis and cell migration (5). This binding has proven to be an important inhibitor of the activated form of protein C (APC) (6). Sequence: N-Terminal Cysteine Physical Appearance: Colorless frozen solution. Solubility: >2mg/ml and <5mg/ml Buffer Composition: 0.05M sodium phosphate, 0.1M sodium chloride, 1mM EDTA, 1mM DTT, pH 6.6 Purity: >98% pure by SDS PAGE 95 (+/-) 5% active by uPA titration Absorbance (280nm): 2.3 E0.1% = 1.0 Concentration = 2.3mg/ml Active Concentration = 2.3mg/ml Kinetic Data: Second order rate constants for inhibition of: uPA = 6.3 X 106 M -1s -1 tPA = 5.7 X 106 M -1s -1 Storage and Stability: Store frozen at -70C - stable for 1 year.

Product Properties

• Molecular Weight: 43