Plasminogen Activator Inhibitor Type 1, wild type, Rat (PAI-1)

Product Overview

• Article Name: Plasminogen Activator Inhibitor Type 1, wild type, Rat (PAI-1)
• Biozol Catalog Number: USB-P4256-31P
• Supplier Catalog Number: P4256-31P
• Alternative Catalog Number: USB-P4256-31P-500
• Manufacturer: US Biological
• Category: Molekularbiologie

Product Description

Plasminogen Activator Inhibitor 1 (PAI-1) is a glycoprotein found in plasma that is implicated in the processes of angiogenesis, hemostasis, tumor metastasis, fibrionlysis, ovulation, embryonic development and inflammation (1). The elevation of PAI-1 has shown to correlate with the prognosis of many cancers including breast cancer (2,3,4). PAI-1 is activated by the glycoprotein vitronectin. Vitronectin binds to PAI-1 and modulates fibrinolysis and cell migration (5). This binding has proven to be an important inhibitor of the activated form of protein C (APC) (6). Appearance: Colorless, frozen solution Solubility: ~2-5mg/ml Absorbance (280nm): 2.5 E0.1% = 1.0 Storage and Stability: Store frozen at -70C Stable for 12 months.

Product Properties

• Molecular Weight: 43
• Purity: >98% pure by SDS PAGE 905% active by uPA titration.
• Form: Supplied as al iquid in 0.05M sodium acetate, 0.1M sodium chloride, 1mM EDTA, pH 5.0.