Important, highly specific inhibitor of the kinase known variously as p38, p40, CSBP, or RK. This kinase is a homolog of MAP kinase. Gallagher, T.F., et al. 2,4,5-Triarylimidazole inhibitors of Il-1 biosynthesis. Bioorg. Med. Chem. Lett. 5: 1171-1176 (1995). Cuenda, A., et al. SB203580 is a specific inhibitor of MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett.. 364: 229-233 (1995). Hazzalin, C.A., et al. Effects of the inhibition of p38/RK MAP kinase on induction of five fos and jun genes by diverse stimuli. Oncogene 15: 2321-2331 (1997). Solubility: Soluble in DMSO at 100mg/ml, soluble in ethanol at 12.5mg/ml with warming, very poorly soluble in water, maximum solubility in plain water is estimated to be about 10-50uM, buffers, serum, or other additives may increase or decrease the aqueous solubility. Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
377.43
Purity:
99% (HPLC, TLC)
Form:
Supplied as a white to off-white powder.
CAS Number:
[152121-47-6]
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