Sarafotoxin S6b (Atractaspis engaddensis) (Sarafotoxin B), CAS [[116303-65-2]]
Biozol Catalog Number:
USB-S0170-01A
Supplier Catalog Number:
S0170-01A
Alternative Catalog Number:
USB-S0170-01A-1
Manufacturer:
US Biological
Category:
Molekularbiologie
Sarafotoxins (SRTXs) are group of toxins present in a venom of Atractaspis engaddensis, and in clinical trials cause similar symptoms to patients diagnosed with acute giardiasis.[1] Together with endothelins (ETs), they form a homogenous family of strong vasoconstrictor isopeptides. Among them, few slightly different substances can be named, as SRTX-a, SRTX-b, SRTX-c, which were initially derived from Atractaspis engaddensis. Each contains twenty-one amino acid residues that spontaneously fold into a defined tertiary structure with two interchain-cysteine linkages (disulfide bonds) and a long hydrophobic tail.[2] There are also other compounds, however, they are mostly derivations of previously mentioned ones. The main differences in the family of endothelin and sarafotoxins appear at N-terminal of peptides, as C-terminal in all of them is almost the same.[3] CAS Number: 116303-65-2 Molecular Formula: C110H159N27O34S5 Molecular Weight: 2564 Appearance: White lyophilized solid Purity (HPLC): ~95% Sequence: Cys-Ser-Cys-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Tyr-Phe-Cys-His-Gln-Asp-Val-Ile--Trp (CSCKDMTDKECLYFCHQDVIW) Modifications: Disulfide bridge between: 1-15, 3-11 Storage and Stability: Lyophilized powder may be stored at 4C for short-term only. Stable for 12 months at -20C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight:
2564
Purity:
95+% HPLC, Mass Spec
Form:
Supplied as a white to off-white lyophilized powder.
CAS Number:
[116303-65-2]
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