Sequestosome 1, Recombinant, Human (SQSTM1, A170, EBI3-associated Protein of 60kD, EBIAP, ORCA, Oxidative Stress Induced-like, OSIL, p60, p62, p62B, Paget Disease of Bone 3, PDB3, Phosphotyrosine-independent Ligand for the Lck SH2
Sequestosome 1, Recombinant, Human (SQSTM1, A170, EBI3-associated Protein of 60kD, EBIAP, ORCA, Oxidative Stress Induced-like, OSIL, p60, p62, p62B, Paget Disease of Bone 3, PDB3, Phosphotyrosine-independent Ligand for the Lck SH2
Sequestosome 1, Recombinant, Human (SQSTM1, A170, EBI3-associated Protein of 60kD, EBIAP, ORCA, Oxidative Stress Induced-like, OSIL, p60, p62, p62B, Paget Disease of Bone 3, PDB3, Phosphotyrosine-independent Ligand for the Lck SH2
Biozol Catalog Number:
USB-S0961-50H
Supplier Catalog Number:
S0961-50H
Alternative Catalog Number:
USB-S0961-50H-100
Manufacturer:
US Biological
Category:
Molekularbiologie
Application:
WB
SQSTM1 is an adapter protein which binds ubiquitin and regulates signaling cascades through ubiquitination. It may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 and play a role in titin/TTN downstream signaling in muscle cells. This protein also may be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels. Mutations in the ubiquitin-associated (UBA) domain of the sequestosome 1 protein commonly cause Pagets disease since the UBA is necessary for aggregate sequestration and cell survival. Recombinant SQSTM1 protein, fused to His-tag at C-terminus, was expressed in E. coli. Source: Recombinant corresponding to aa1-356 of human SQSTM1 6x His tagged expressed in E. coli. AA Sequence: MAMSYVKDDI FRIYIKEKKE CRRDHRPPCA QEAPRNMVHP NVICDGCNGP VVGTRYKCSV CPDYDLCSVC EGKGLHRGHT KLAFPSPFGH LSEGFSHSRW LRKVKHGHFG WPGWEMGPPG NWSPRPPRAG EARPGPTAES ASGPSEDPSV NFLKNVGESV AAALSPLGIE VDIDVEHGGK RSRLTPVSPE SSSTEEKSSS QPSSCCSDPS KPGGNVEGAT QSLAEQMRKI ALESEGRPEE QMESDNCSGG DDDWTHLSSK EVDPSTGELQ SLQMPESEGP SSLDPSQEGP TGLKEAALYP HLPPEADPRL IESLSQMLSM GFSDEGGWLT RLLQTKNYDI GAALDTIQYS KHPPPLLEHH HHHH Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
