Sincalide corresponds to the C-terminal octapeptide of cholecystokinin (CCK) which acts on receptors within the gallbladder wall causing it to contract. Cholecystokinin (CCK) is a hormone originally isolated from porcine intestinal mucosa and described as a linear 33-amino acid peptide containing a sulfated tyrosine, which is essential for its biological activity. It has been found in mammals in both the digestive tract and the central nervous system. Among its multiple biological functions, this hormone stimulates pancreatic exocrine secretion, gallbladder contraction, and intestine motility and may also act as a neurotransmitter/neuromodulator in the central nervous system. Sincalide also called CCK-8 has a molecular formula of C49H62N10O16S3, H-Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2 having a MW of 1143.29 Dalton. Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile ddH2O, 0.1% HSA or BSA. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight:
1143.29
Purity:
98% as determined by RP-HPLC
Form:
Supplied as a lyophilized powder. Reconstitute in sterile ddH2O, 0.1% HSA or BSA to 0.1mg/ml.
CAS Number:
[25126-32-3]
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