| Sterigmatocystin is a xanthone isolated by a number of groups in the 1950s as a mycotoxin produced by several species of Aspergillus associated with food and grain contamination. Sterigmatocystin is structurally related to the aflatoxins and while it is considered to be mutagenic, teratogenic and carcinogenic, it is less widespread and potent than the aflatoxins. Sterigmatocystin in the presence of microsomes covalently binds to DNA. It uncouples oxidative phosphorylation but, unlike the aflatoxins, does not induce mitochondrial swelling or hinder Ca2+-induced swelling of mitochondria. More recently, sterigmatocystin has been shown to be an inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) with selectivity for the ACAT2 isoenzyme. Source: Aspergillus sp. (strain WDMH51). Synonyms: (3aR,12cS)-3a,12c-Dihydro-8-hydroxy-6-methoxy-7H-furo[3,2:4,5]furo[2,3-c]xanthen-7-one, 3a,12c-Dihydro-8-hydroxy-6-methoxy-7H-furo[3,2:4,5]furo[2,3-c]xanthen-7-one, (3aR-cis)-3a,12c-Dihydro-8-hydroxy-6-methoxy-7H-furo[3,2:4,5]furo[2,3-c]xanthen-7-one, NSC 201423, NSC 204985, Sterigmatocystine CAS No: 10048-13-2 Molecular Formula: C18H12O6 Molecular Weight: 324.3 Purity: 98% (HPLC Appearance: Pale yellow powder Solubility: Soluble in DMSO, ethanol, methanol, pyridine or acetone. Method of Determining identity: 1H-NMR Spectometry Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
