This peptide represents a sequence within the conserved region of the carboxyl terminus of the group A streptococcal M protein. Antibodies to this peptide were able to opsonise isolates of streptococci from Aboriginal and Thai subjects with acute rheumatic fever as well as reference strains of different M types. It may therefore find application in the preparation of a vaccine for rheumatic fever. Sequence: H-Leu-Arg-Arg-Asp-Leu-Asp-Ala-Ser-Arg-Glu-Ala-Lys-Lys-Gln-Val-Glu-Lys-Ala-Leu-Glu-OH Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight:
2355.68
Purity:
97.7% (HPLC)
Form:
Supplied as a lyophilized powder in TFA salt.
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