Streptonigrin (Bruneomycin, Nigrin, Rufocromomycin, Valacidin, Antibiotic RP 5278), CAS [[3930-19-6]]

Product Overview

• Article Name: Streptonigrin (Bruneomycin, Nigrin, Rufocromomycin, Valacidin, Antibiotic RP 5278), CAS [[3930-19-6]]
• Biozol Catalog Number: USB-S7975-09
• Supplier Catalog Number: S7975-09
• Alternative Catalog Number: USB-S7975-09-1,USB-S7975-09-5
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

Streptonigrin (2.5-12.5uM) induces DNA cleavage by calf thymus topoisomerase II in a concentration-dependent manner. It induces phage production in S. typhimurium when used at concentrations ranging from 1-10ug/ml. Streptonigrin (10ug/ml) inhibits DNA synthesis in and reduces survival of S. typhimurium bacteria. Streptonigrin is bactericidal against E. coli in an iron-dependent manner, an effect that is blocked by the iron chelators deferoxamine and orthophenanthroline. Streptonigrin (40 nM) is cytotoxic to human HT-29 colon carcinoma cells but not to BE colon carcinoma cells in which NAD(P)H:quinone oxidoreductase is not expressed. Streptonigrin (0.001-0.1ug/ml) inhibits mitosis and induces chromatin breaks in human leukocytes in a concentration-dependent manner. In vivo, streptonigrin (0.05mg/kg, i.p.) increases the mean survival time in rats infected with Rauscher virus. Source: Streptomyces sp. MST-AS5763 Synonyms: 5278RP, AO 50165L302, Abbott Crystalline antibiotic, Bruneomycin, NSC 45383, NSC 56748, NSC 83950, Nigrin, Rufocromomycin, SN, STP, Streptonigran, Streptonigrin, 5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic Acid, (4R)-5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolinyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methyl-2-pyridinecarboxylic Acid, (R)-Streptonigrin CAS No: 3930-19-6 Molecular Formula: C25H22N4O8 Molecular Weight: 506.46 Apperance: Brown black solid Purity: 95% Solubility: Soluble in DMSO. Storage and Stability: May be stored at 4C for short-term only. For long-term storage store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 506.5
• Purity: 95%
• Form: Brown black solid
• CAS Number: [3930-19-6]