Neuropeptide found in high concentrations in the gut. When released from afferent nerves, causes a neurogenic inflammatory response, including mast cell degranulation. Induces Ca2+ mobilization. Reported to activate Go alpha, Gq/11 alpha, and Gs alpha subunits in CHO cells via activation of substance P receptors. Also reported to induce superoxide production in neutrophils. Molecular Weight: 1347.6 AA Sequence: H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 Solubility: 5% Acetic acid Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight:
1347.6
Purity:
~96% (HPLC)
Form:
Supplied as a lyophilized powder.
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