An active metabolite of Sulindac. Inhibits cyclooxygenase, but induces apoptosis by a cyclooxygenase-independent mechanism. Inhibition of Ras activation of Ref-1. Impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP by p120GAP. CAS No: 32004-67-4 Molecular Formula: C20H17FO2S Melting Point: 177-182C Solubility: DMSO (Slightly), Methanol (Slightly, Heated) Method for Determining Identity: Proton NMR Spectroscopic Analysis TLC Conditions: Dichloromethane: Methanol, 9:1, Visualized with UV and AMCS, Single spot, Rf = 0.56. Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
340.41
Purity:
~90%
Form:
Yellow to Orange Solid
CAS Number:
[32004-67-4]
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