Survivin, Control Peptide (Apoptosis Inhibitor 4, Apoptosis Inhibitor-4, API4, Apoptosis Inhibitor Survivin, Baculoviral IAP Repeat-containing 5, BIRC5, BIRC-5, EPR1, EPR-1, IAP4)
Catalog Number:
USB-S8500-01W
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| Article Name: | Survivin, Control Peptide (Apoptosis Inhibitor 4, Apoptosis Inhibitor-4, API4, Apoptosis Inhibitor Survivin, Baculoviral IAP Repeat-containing 5, BIRC5, BIRC-5, EPR1, EPR-1, IAP4) |
| Biozol Catalog Number: | USB-S8500-01W |
| Supplier Catalog Number: | S8500-01W |
| Alternative Catalog Number: | USB-S8500-01W-100 |
| Manufacturer: | US Biological |
| Category: | Molekularbiologie |
| Application: | ELISA |
| Apoptosis is a form of cell death that permits the removal of damaged, senescent or unwanted cells in multicellular organisms, without damage to the cellular microenvironment. Survivin is a member of the inhibitor of apoptosis (IAP) gene family, which encodes negative regulatory proteins that prevent apoptotic cell death. repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. Survivin appears to have an important role in regulating apoptosis at cell cycle checkpoint(s). Survivin expression is highly cell cycle-regulated, and is detectable in the nucleus selectively at the G2/M phase. Human Survivin: Isoform 1-142aa, 16.4kD, Isoform 2-165aa, 18.6kD, Isoform 3 -137aa, 15.6kD, Isoform 4-120aa, 13.8kD, Isoform 5-117aa, 13.5kD, Isoform 6 -78aa, 9kD, Isoform 7-74aa, 8.5kD. Human chromosome: 17q25. Mainly expressed in fetal kidney and liver, and to lesser extent, lung and brain, abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Source: Synthetic peptide corresponding to 21aa of human Survivin, N-terminal. Molecular Weight: ~3kD Applications: Suitable for use in ELISA. Not suitable for use in Western Blot. Other applications not tested. Recommended Dilution: ELISA: 50-100ng control peptide/well) Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
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