Imidazotetrazine alkylating agent. An antineoplastic. A cell-permeable, orally bioavailable, blood-brain barrier-permeant MTIC [5-(3-methyltriazen-1-yl-)-imidazole-4-carboxamide] prodrug whose in vivo DNA alkylating activity is employed in anticancer therapy. MGMT (O6-methylguanine DNA methyl transferase) repairs TMZ-damaged DNA lesion by covalently transferring O6-methylation on guanine residues to a cysteine residue on the MGMT, forming the basis of TMZ-resistance in cancer treatment. CAS No: 85622-93-1 Molecular Formula: C6H6N6O2 Solubility: Dichloromethane, DMSO, Methanol Primary Target: DNA guanine residues Molar Mass: 194.2 Melting Point: >177C (dec.) Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
194.2
Form:
White to Off-White Solid
CAS Number:
[85622-93-1]
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