TTA is a novel thio-fatty acid which cannot undergo beta-oxidation. It induces apoptosis in IPC-81 leukemia cells via depolarization of mitochondrial membrane potential and inhibits glioma cell proliferation. TTA completely prevents high fat diet-induced insulin resistance and adiposity in Wistar rats. Activates rodent PPARs with rank order PPARalpha>PPARdelta>PPARgamma. Synonyms: TTA, 1-Mono(carboxymethylthio)tetradecane CAS No: 2921-20-2 Molecular Weight: 288.49 Molecular Formula: C16H32O2S Melting Point: 63-66C Solubility: Dichloromethane (Slightly), DMSO (Slightly) Method for Determining Identity: Proton NMR Spectroscopic Analysis and Mass Spectrometric Analysis TLC Conditions: SiO2, Dichloromethane: Methanol: Acetic Acid, 9.5ml: 0.5ml: 10drops, Visualized with UV and AMCS, Single spot Rf=0.65. Appearance: Supplied as a white solid. Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
288.49
Purity:
~90%
Form:
Supplied as a white solid.
CAS Number:
[2921-20-2]
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