TMEM173 (Transmembrane Protein 173, Endoplasmic Reticulum Interferon Stimulator, ERIS, FLJ38577, Mediator of IRF3 Activation, MITA, hMITA, MPYS, NET23, Stimulator of Interferon Genes Protein, STING, hSTING), Rabbit
Biozol Catalog Number:
USB-T6020-50
Supplier Catalog Number:
T6020-50
Alternative Catalog Number:
USB-T6020-50-100
Manufacturer:
US Biological
Host:
Rabbit
Category:
Antikörper
Application:
IHC
Immunogen:
Synthetic peptide corresponding to aa310-360 of human STING.
STING is a 379aa containing signaling protein that acts as an important component of innate immune signaling. This signaling protein is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. STING may have translocon function, the translocon possibly being able to influence the induction of type I interferons and is also involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) thus facilitating the detection of intracellular viral RNA species as well as B-form DNA and mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Generally seen in endoplasmic reticulum membrane, cell membrane and mitochondrion outer membrane, it is ubiquitously expressed in most of tissues. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (formalin fixed paraffin embedded): 5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
