TL1A (TNFSF15, Tumor Necrosis Factor Ligand Superfamily Member 15), Rabbit
Biozol Catalog Number:
USB-T8038-08
Supplier Catalog Number:
T8038-08
Alternative Catalog Number:
USB-T8038-08-100
Manufacturer:
US Biological
Host:
Rabbit
Category:
Antikörper
Application:
WB
Immunogen:
Synthentic peptide, TL1A antibody was raised against recombinant human TL1A (GenBank accession no. AAM77366).
Members in the TNF and its receptor superfamilies regulate immune responses and induce apoptosis. DR3 (also termed Wsl-1, Apo-3, TRAMP, and LARD) (1-5) is preferentially expressed by T lymphocytes and upregulated during T cell activation. The ligand for DR3 was recently identified and designated TL1A (6). TL1A also binds decoy receptor DcR3/TR6 (7,8), which is expressed in several lung and colon carcinomas and in some normal tissues. TL1A induces apoptosis and NF-kappaB activation in DR3 expressing cells, which is antagonized by DcR3. TL1A is upregulated by proinflammatory cytokines TNF and IL-1. TL1A is a longer variant of TL1 (also called VEGI). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ugml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
