TLR7 (Toll Like Receptor 7, TLR-7, PRO285, UNQ248), Clone: [4F4], Mouse, Monoclonal

Product Overview

• Article Name: TLR7 (Toll Like Receptor 7, TLR-7, PRO285, UNQ248), Clone: [4F4], Mouse, Monoclonal
• Biozol Catalog Number: USB-T8050-71B
• Supplier Catalog Number: T8050-71B
• Alternative Catalog Number: USB-T8050-71B-100
• Manufacturer: US Biological
• Host: Mouse
• Category: Antikörper
• Application: ELISA, FC, WB
• Immunogen: Recombinant protein corresponding to aa451-500 from human TLR7, expressed in E. coli.

Product Description

TLR7 (toll-like receptor 7) is a 121kD type I transmembrane protein which belongs to the toll-like receptor (TLR) family, and is predominantly expressed in the spleen, lung and placenta. TLRs are highly conserved proteins which play a key role in activation of innate immunity, through the recognition of distinct molecular patterns expressed by infectious agents. TLR7 recognizes and interacts with single-stranded RNA (ssRNA) derived from viruses such as influenza , HIV-1 (human immunodeficiency virus type I) and Sendai, and some siRNAs, resulting in the activation of the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway, and the production of proinflammatory signaling molecules. Applications: Suitable for use in ELISA, Flow Cytometry and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [4F4]
• NCBI: 057646
• UniProt: Q9NYK1
• Purity: Purified by Protein A affinity chromatography from tissue culture supernatant.
• Form: Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 10% glycerol.