Recombinant protein corresponding to Met360-Leu516 from human TLR7, expressed in E. coli.
Toll-like receptor 7 (TLR7) is a 120kD (predicted, unglycosylated) type I transmembrane glycoprotein and member of the Toll-like receptor family. Human TLR7 is synthesized as a 1049aa precursor that contains a 26aa signal sequence, an 803aa extracellular domain (ECD), a 21aa transmembrane sequence, and a 189aa cytoplasmic domain. Mature human TLR7 is 81% aa identical to mature mouse TLR7. TLR7 is detected in brain, placenta, spleen, stomach, small intestine, lung, and in plasmacytoid pre-dendritic cells. Functionally, TLR7 participates in the innate immune response to microbial agents. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry (Intracellular): 10ul labels 10e6 cells Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C before opening. DO NOT FREEZE! Stable at 4C as an undiluted liquid. Stable for 12 months after receipt at 4C. Freezing PerCP conjugates will result in a substantial loss of activity. PerCP conjugates are sensitive to light.
