TORC2 (TORC 2, TORC-2, Transducer of Regulated CREB Protein 2, CREB-regulated Transcription Coactivator 2, CRTC2, Transducer of Regulated cAMP Response Element-binding Protein), IgG2b, Clone: [11D49], Mouse, Monoclonal
Biozol Catalog Number:
USB-T8067-21D
Supplier Catalog Number:
T8067-21D
Alternative Catalog Number:
USB-T8067-21D-100
Manufacturer:
US Biological
Host:
Mouse
Category:
Antikörper
Application:
WB
Immunogen:
Recombinant corresponding to human TORC2 expressed in E. coli (Q53ET0).
TORC2, also known as CREB-regulated transcription co-activator 1(crtc2), is an approximately 75 kD protein that functions as a co-activator for CREB1 in promoting transcription through both consensus and variant cAMP response element (CRE) sites. TORC2 activity is important in regulating the expression of genes involved in cellular energy metabolism. Its O-glycosylation triggers TORC2-dependent induction of hepatic gluconeogenic enzymes. It mediates hypothalamic glucose sensing and also the sensing of endoplasmic reticulum stress. In addition, TORC2 contributes to the transcription of HTLV-1 genes and the activation of latent EBV infections. Within(aa453-613), human TORC2 shares 84% aa sequence identity with mouse TORC2. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.01ug/ml Optimal dilutions to be determined by the researcher. Hybridoma: Myeloma cells with B cells from Balb/c mice. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
