TPX2 (Targeting Protein for Xklp2, Differentially Expressed in Cancerous and Non-cancerous Lung Cells 2, DIL-2, Hepatocellular Carcinoma-associated Antigen 519, Protein fls353, Restricted Expression Proliferation-associated Protei
TPX2 (Targeting Protein for Xklp2, Differentially Expressed in Cancerous and Non-cancerous Lung Cells 2, DIL-2, Hepatocellular Carcinoma-associated Antigen 519, Protein fls353, Restricted Expression Proliferation-associated Protei
TPX2 (Targeting Protein for Xklp2, Differentially Expressed in Cancerous and Non-cancerous Lung Cells 2, DIL-2, Hepatocellular Carcinoma-associated Antigen 519, Protein fls353, Restricted Expression Proliferation-associated Protei
Biozol Catalog Number:
USB-T8100-05H
Supplier Catalog Number:
T8100-05H
Alternative Catalog Number:
USB-T8100-05H-100
Manufacturer:
US Biological
Host:
Mouse
Category:
Antikörper
Application:
WB
Immunogen:
Amino acids 1-220 from human TPX2.
The TPX2 protein, also known as targeting protein for Xklp1, restricted expression proliferation associated protein p100, and differentially expressed in cancer and non-cancerous lung cells protein 2 (DIL2), is a 100kD nuclear protein that contains two coiled-coil domains. The TPX2 protein is strictly associated with spindle pole and mitotic spindle during mitosis. In the G2/S position of the cell cycle, TPX2 is diffusely distributed throughout nucleus. TPX2 has been shown to be highly expressed in lung carcinomas cell lines, but not in normal lung tissues. TPX2 is thought to be required for the Ran-GTP dependent assembly of microtubules around chromosomes required to generate stable bipolar spindle with overlapping anti-parallel microtubule arrays and may also be involved in targeting Aurora-A kinase to the mitotic spindle. TPX2 has been shown to interact with a large number of proteins including serine/threonine protein kinase 6, ribosomal protein 6, Bop-1, a-tubulin, and nucleolin among others. TPX2 can be modified by phosphorylation on serine 738. Applications: Suitable for use in Western Blot and Immunocytochemistry . Other applications not tested. Recommended Dilution: Western Blot: 0.2-1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
