TANK, Recombinant, Human, aa1-119 (TRAF Interacting TANK, Protein TANK, Isoform b, I-TRAF, TRAF2)

Product Overview

• Article Name: TANK, Recombinant, Human, aa1-119 (TRAF Interacting TANK, Protein TANK, Isoform b, I-TRAF, TRAF2)
• Biozol Catalog Number: USB-T8171-80A
• Supplier Catalog Number: T8171-80A
• Alternative Catalog Number: USB-T8171-80A-100
• Manufacturer: US Biological
• Category: Molekularbiologie

Product Description

TANK, also known as TRAF (tumor necrosis factor receptor-associated Factor)-interacting protein, is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby proposing that this protein is an inhibitor of TRAF function that regulates TRAF protein activity by sequestering TRAFs in a latent state in the cytoplasm. Overexpression of TANK inhibits TRAF2-mediated NF-Kappa-B activation signaled by CD40 and both TNF receptors and inhibits LMP1-mediated NF-kappa-B activation by blocking the association of TRAF2 with LMP1. Recombinant protein corresponding to aa1-119 from human TANK, expressed in E. coli. Molecular Weight: ~13.6kD (MALDI-TOF) Amino Acid Sequence: MDKNIGEQLN KAYEAFRQAC MDRDSAVKEL QQKTENYEQR IREQQEQLSL QQTIIDKLKS QLLLVNSTQD NNYGCVPLLE DSETRKNNLT LDQPQDKVIS GIAREKLPKV DIASAESSI Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 13.6
• NCBI: 597841
• UniProt: Q92844
• Purity: 90% by SDS PAGE, Purified by using conventional chromatography techniques.
• Form: Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0.