TRAF2, CT (TNF Receptor-associated Factor 2, Tumor Necrosis Factor Type 2 Receptor-associated Protein 3, TRAP3), Rabbit
Catalog Number:
USB-T8171-94L
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| Article Name: | TRAF2, CT (TNF Receptor-associated Factor 2, Tumor Necrosis Factor Type 2 Receptor-associated Protein 3, TRAP3), Rabbit |
| Biozol Catalog Number: | USB-T8171-94L |
| Supplier Catalog Number: | T8171-94L |
| Alternative Catalog Number: | USB-T8171-94L-200 |
| Manufacturer: | US Biological |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | ELISA, IHC, WB |
| Immunogen: | KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 343-372 in the C-terminal region of human TRAF2, UniProt Accession Q12933. |
| TRAF2 is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Applications: Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000 Immunohistochemistry (FFPE): 1:10-1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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