TRAIL (TNF-Related Apoptosis Inducing Ligand, Apo2 Ligand), Clone: [4H289], Mouse, Monoclonal
Catalog Number:
USB-T8180-04C
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| Article Name: | TRAIL (TNF-Related Apoptosis Inducing Ligand, Apo2 Ligand), Clone: [4H289], Mouse, Monoclonal |
| Biozol Catalog Number: | USB-T8180-04C |
| Supplier Catalog Number: | T8180-04C |
| Alternative Catalog Number: | USB-T8180-04C-100 |
| Manufacturer: | US Biological |
| Host: | Mouse |
| Category: | Antikörper |
| Application: | WB |
| Immunogen: | Peptide corresponding to amino acids 17-35 of human TRAIL. This peptide sequence has been shown to be involved in TRAIL and DR5 (TRAIL-R2) interaction. |
| Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel member in the TNF family was recently identified and designated TRAIL (for TNF-related apoptosis-inducing ligand) and Apo-2L (for Apo-2 ligand) (1,2). TRAIL is a type II membrane protein and expressed in a variety of human tissues. Two novel death domain containing receptors DR4 and DR5 have been identified as the receptor for TRAIL3-6. Like TNF and Fas ligand, TRAIL induces apoptosis and NF-kB activation in many tissues and cells. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Whole cell lysate from Jurkat cells can be used as positive control and a 32kD band, which represents a membrane bound form of TRAIL, is detected. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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