Transferrin receptor is a 190kD Type II membrane glycoprotein which consists of two subunits of 95kD. It is expressed on activated lymphocytes, macrophages and monocytes. It binds Fe (Apo) transferrin. The gene coding for the antigen is located on the q-arm of chromosome 3. The ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias and lymphomas. Transferrin receptors are also present on reticulocytes, but are lost during maturation into erythrocytes.Transferrin receptor (CD71) has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer. Applications: Suitable for use in Flow Cytometry and Western Blot. Other applications have not been tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clonality:
Monoclonal
Clone Designation:
[T56/14]
Isotype:
IgG1
Purity:
95%
Form:
Supplied as a liquid in PBS, pH 7.0.
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