TSC2, phosphorylated (Ser664) (Tuberin, Tuberous Sclerosis 2 Protein, TSC4), Rabbit

Product Overview

• Article Name: TSC2, phosphorylated (Ser664) (Tuberin, Tuberous Sclerosis 2 Protein, TSC4), Rabbit
• Biozol Catalog Number: USB-T9100-25G2
• Supplier Catalog Number: T9100-25G2
• Alternative Catalog Number: USB-T9100-25G2-200
• Manufacturer: US Biological
• Host: Rabbit
• Category: Antikörper
• Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Ser664 of human TSC2 (KLH).

Product Description

Mutations in TSC2 lead to tuberous sclerosis complex. The protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking. Applications: Suitable for use in ELISA and Dot Blot. Other applications not tested. Recommended Dilution: ELISA: 1:1000 Dot Blot: 1:500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Product Properties

• NCBI: 000539
• UniProt: P49815
• Purity: Purified by Protein A and peptide affinity chromatography.
• Form: Supplied as a liquid in PBS, 0.09% sodium azide.