Ubiquitin, Rabbit
Catalog Number:
USB-U0999-05B
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| Article Name: | Ubiquitin, Rabbit |
| Biozol Catalog Number: | USB-U0999-05B |
| Supplier Catalog Number: | U0999-05B |
| Alternative Catalog Number: | USB-U0999-05B-200 |
| Manufacturer: | US Biological |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | IF, IHC, IP, WB |
| Immunogen: | Native bovine Ubiquitin, conjugated to KLH. |
| Ubiquitin is a highly conserved, small regulatory protein that plays a pivotal role in maintaining cellular protein homeostasis through the ubiquitin-proteasome system (UPS) and autophagy pathways. By tagging damaged, misfolded, or excess proteins for degradation, ubiquitin ensures proper protein turnover and prevents toxic protein accumulation-an essential function in long-lived, post-mitotic neurons. In the context of neuroscience, ubiquitin is critically involved in synaptic plasticity, axonal transport, and neuronal survival. Dysregulation of ubiquitin signaling has been strongly implicated in the pathogenesis of major neurodegenerative diseases, including Alzheimers disease, Parkinsons disease, Huntingtons disease, and amyotrophic lateral sclerosis (ALS). These disorders are often characterized by the accumulation of ubiquitin-positive protein aggregates, indicating a breakdown in proteostasis mechanisms. Multiple genes encode ubiquitin precursors, including UBB, UBC, UBA52, and RPS27A, each contributing to the dynamic regulation of ubiquitin pools in neurons. Mutations or altered expression in these genes, or in components of the UPS, can disrupt neuronal function and accelerate neurodegeneration. As a master regulator of protein quality control, ubiquitin is a key molecular target in neurodegenerative disease research. Understanding its signaling networks offers promising avenues for therapeutic intervention aimed at restoring proteostasis and halting disease progression. Applications: Suitable for use in Western Blot, Immunohistochemistry, Immunoprecipitation and Immunocytochemistry/Immunofluorescence. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000 Immunohistochemistry (paraffin): 1:100 Immunocytochemistry/Immunofluorescence: 1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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