Uncoupling Protein 3 (UCP 3, UCP3, Mitochondrial Uncoupling Protein 3, Solute Carrier Family 25 Member 9, SLC25A9), Rabbit
Catalog Number:
USB-U1622-03B
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| Article Name: | Uncoupling Protein 3 (UCP 3, UCP3, Mitochondrial Uncoupling Protein 3, Solute Carrier Family 25 Member 9, SLC25A9), Rabbit |
| Biozol Catalog Number: | USB-U1622-03B |
| Supplier Catalog Number: | U1622-03B |
| Alternative Catalog Number: | USB-U1622-03B-100 |
| Manufacturer: | US Biological |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | WB |
| Immunogen: | Synthetic peptide corresponding to aa125-175 of human UCP3. Species sequence homology: bonve (84%), canine (90%) and porcine (94%). |
| The uncoupling proteins (UCPs) are found in the inner mitochondrial membranes and belong to a family of mitochondrial anion transport proteins that include the phosphate and oxologutarate carriers and the ADP/ATP translocator. Three UCP subtypes have been identified and cloned. UCP 1 is abundantly expressed in brown adipose tissue of mammals. UCP 1 allows proton re-entry into the mitochondrial matrix without involving the F0-F1 ATPase which produces heat instead of ATP. It is thought that UCP 2 and 3 also dissipate the mitochondrial proton gradient produced by the respiratory chain in cells and tissues within which they are expressed. Studies have shown UCP 2 to be expressed by a variety of tissues. UCP 3 is expressed predominantly in brown adipose tissue, skeletal muscle, at lower levels in heart and smooth muscle, and is absent in liver and kidney. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human, mouse and rat heart lysate Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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