Urokinase Plasminogen Activator (uPA) (HRP), IgG2a, Clone: [2Q486 10D7.2], Mouse, Monoclonal
Catalog Number:
USB-U2615-HRP
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| Article Name: | Urokinase Plasminogen Activator (uPA) (HRP), IgG2a, Clone: [2Q486 10D7.2], Mouse, Monoclonal |
| Biozol Catalog Number: | USB-U2615-HRP |
| Supplier Catalog Number: | U2615-HRP |
| Alternative Catalog Number: | USB-U2615-HRP-100 |
| Manufacturer: | US Biological |
| Host: | Mouse |
| Category: | Antikörper |
| Application: | ELISA, WB |
| Immunogen: | Amino-terminal fragment of Urokinase Plasminogen Activator. |
| Urokinase Plasminogen Acitivator is a serine protease (SERPIN) that converts plasminogen into the active protease plasmin. uPA is secreted from cells as an inactive ~55kDa precursor which is activated to the two-chain form consisting of an A and B-chain. The active high MW form is further processed by removal of an amino-terminal fragment to an active low MW form (~35kDa). uPA is a serine protease that activates plasminogen to plasmin. uPA is involved in the degradation of the vascular basement membrane and extracellular matrix. By catalyzing plasmin formation, the uPA can generate widespread extracellular proteolysis and thereby play an important role in physiological and pathological processes. High levels of uPA and plasminogen activator inhibitor type 1 (PAI-1) in breast cancer tissue extracts have been associated with rapid disease progression. The malignant phenotype of prostatic tumor cells correlates with the expression of both uPA and its cell-membrane receptor (uPAR). Applications: Suitable for use in Western Blot and ELISA. Other applications have not been tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20C. Aliquots are stable at -20C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Note: Applications are based on unconjugated antibody. |
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