Urotensin II (UII, U-II, Urotensin-2, UTS2, PRO1068, UNQ525/PRO1068), Rabbit
Biozol Catalog Number:
USB-U2800-02C
Supplier Catalog Number:
U2800-02C
Alternative Catalog Number:
USB-U2800-02C-200
Manufacturer:
US Biological
Host:
Rabbit
Category:
Antikörper
Application:
ELISA, RIA
Immunogen:
Synthetic peptide corresponding to Glu-Thr-Pro-Asp-Cys-Phe-Trp- Lys-Tyr-Cys-Val (Disulfide Bridge: Cys5-Cys10) from human Urotensin II.
Urotensin II (U-II) is a cyclic heptapeptide that functions both as a potent vasoconstrictor and a neurotransmitter/ neuromodulator. U-II circulates in the plasma as a zymogen, and is activated by the urotensin converting enzyme. U-II is the endogenous ligand for the G-protein coupled receptor 14 (GPR14), recently renamed the UT receptor. Changes in the expression of U-II and its receptor have been associated with cardiovascular and renal diseases, including atherosclerosis, myocardial infarction, and diabetic nephropathy. Applications: Suitable for use in ELISA and Radioimmunoassay. Other applications not tested. Recommended Dilution: Radioimmunoassay: 0.24ug/ml will bind ~30% in a system using human 125I-Urotensin II as a tracer. Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Purity:
Purified by Protein A affinity chromatography.
Form:
Supplied as a lyophilized powder from PBS, pH 7.5. Reconstitute with 200ul sterile ddH2O.
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