URP1, ID (Kindlin Syndrome Protein, Kindlerin, Kindlin-1, Unc-112-related Protein 1, Fermitin Family Homolog 1, C20orf42, KIND1, FERMT1), Clone: [4A5.14], Mouse, Monoclonal
Catalog Number:
USB-U3005-02
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| Article Name: | URP1, ID (Kindlin Syndrome Protein, Kindlerin, Kindlin-1, Unc-112-related Protein 1, Fermitin Family Homolog 1, C20orf42, KIND1, FERMT1), Clone: [4A5.14], Mouse, Monoclonal |
| Biozol Catalog Number: | USB-U3005-02 |
| Supplier Catalog Number: | U3005-02 |
| Alternative Catalog Number: | USB-U3005-02-100 |
| Manufacturer: | US Biological |
| Host: | Mouse |
| Category: | Antikörper |
| Application: | IHC, WB |
| Immunogen: | GST-tagged recombinant protein corresponding to human Kindlin-1. |
| The Kindlin family is a group of focal adhesion proteins that have recently become a point of interest because of their ability to bind and activate integrins. Abnormalities in this ability have linked Kindlin to several diseases, both inherited and acquired, such as Kindler syndrome, cancer, and leukocyte adhesion deficiency. Specifically associated with Kindler syndrome, is the isoform Kindlin-1 which plays a key role in adhering the actin cytoskeleton to the extracellular matrix of basal keratinocytes. Kindlin-1 may also be involved in tumor growth by modulating TGF-beta 1 signaling (Shi, 2007). It is most widely expressed in the brain, kidney, colon, placenta, skeletal muscle, adrenal gland, and prostate. Applications: Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5ug/ml detects Kindlin-1 in 10ug of HeLa cell lysate. Optimal dilutions to be determined by the researcher. Positive Control: HeLa cell lysate Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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