URP1, ID (Kindlin Syndrome Protein, Kindlerin, Kindlin-1, Unc-112-related Protein 1, Fermitin Family Homolog 1, C20orf42, KIND1, FERMT1) (Biotin), Clone: [4A5.14], Mouse, Monoclonal
Catalog Number:
USB-U3005-02-BIOTIN
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| Article Name: | URP1, ID (Kindlin Syndrome Protein, Kindlerin, Kindlin-1, Unc-112-related Protein 1, Fermitin Family Homolog 1, C20orf42, KIND1, FERMT1) (Biotin), Clone: [4A5.14], Mouse, Monoclonal |
| Biozol Catalog Number: | USB-U3005-02-BIOTIN |
| Supplier Catalog Number: | U3005-02-Biotin |
| Alternative Catalog Number: | USB-U3005-02-BIOTIN-100 |
| Manufacturer: | US Biological |
| Host: | Mouse |
| Category: | Antikörper |
| Application: | IHC, WB |
| Immunogen: | GST-tagged recombinant protein corresponding to human Kindlin-1. |
| The Kindlin family is a group of focal adhesion proteins that have recently become a point of interest because of their ability to bind and activate integrins. Abnormalities in this ability have linked Kindlin to several diseases, both inherited and acquired, such as Kindler syndrome, cancer, and leukocyte adhesion deficiency. Specifically associated with Kindler syndrome, is the isoform Kindlin-1 which plays a key role in adhering the actin cytoskeleton to the extracellular matrix of basal keratinocytes. Kindlin-1 may also be involved in tumor growth by modulating TGF-beta 1 signaling (Shi, 2007). It is most widely expressed in the brain, kidney, colon, placenta, skeletal muscle, adrenal gland, and prostate. Applications: Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Positive Control: HeLa cell lysate Storage and Stability: Store product at 4C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20C. Aliquots are stable at -20C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Note: Applications are based on unconjugated antibody. |
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