Valosin Containing Protein, CT (VCP, Valosin-containing Protein, 15S Mg(2+)-ATPase p97 Subunit, ATPase p97, IBMPFD, MGC131997, MGC148092, MGC8560, p97, Transitional Endoplasmic Reticulum ATPase, TER ATPase, TER-ATPase, TERA, Yeast
Catalog Number:
USB-V1035-20E
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| Article Name: | Valosin Containing Protein, CT (VCP, Valosin-containing Protein, 15S Mg(2+)-ATPase p97 Subunit, ATPase p97, IBMPFD, MGC131997, MGC148092, MGC8560, p97, Transitional Endoplasmic Reticulum ATPase, TER ATPase, TER-ATPase, TERA, Yeast |
| Biozol Catalog Number: | USB-V1035-20E |
| Supplier Catalog Number: | V1035-20E |
| Alternative Catalog Number: | USB-V1035-20E-200 |
| Manufacturer: | US Biological |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | ELISA, WB |
| Immunogen: | Synthetic peptide selected from the C-terminal region of human VCP (KLH). |
| Valsolin Containing Protein (VCP) is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. p97/VCP (valosin containing protein) belongs to the AAA ATPase family, predicted molecular weight 97kD. VCP, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. VCP has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation. Valosin-containing protein (VCP or p97) belongs to the AAA (ATPase associated activities) family and acts as a molecular chaperone to a wide variety of cellular activities. Some of these activities include the alteration of both nuclear and mitotic golgi membranes, ubiquitin-proteasome dependent protein degradation, regulation of the NF-kappa b pathway, and extraction of membrane proteins. VCP has been shown to contain a substrate binding domain (N) and two conserved ATPase domains (D1 and D2). The three dimensional structure of VCP resembles that of a cylinder with the D1 and D2 stacked upon one another in a homo-hexameric ring formation. VCP is involved in the formation of neuronal inclusion bodies in neurodegenerative disease such as Parkinsons Disease. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-1:500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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