VEGFR3 (Vascular Endothelial Growth Factor Receptor 3, VEGFR-3, Fms-like Tyrosine Kinase 4, FLT-4, Tyrosine-protein Kinase Receptor FLT4, FLT4), IgG1, Rabbit

Product Overview

• Article Name: VEGFR3 (Vascular Endothelial Growth Factor Receptor 3, VEGFR-3, Fms-like Tyrosine Kinase 4, FLT-4, Tyrosine-protein Kinase Receptor FLT4, FLT4), IgG1, Rabbit
• Biozol Catalog Number: USB-V2110-20P
• Supplier Catalog Number: V2110-20P
• Alternative Catalog Number: USB-V2110-20P-100
• Manufacturer: US Biological
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, WB
• Immunogen: Synthetic peptide corresponding to 20aa of human FLT4, C-terminal, Cytoplasmic domain (KLH).

Product Description

Embryonic vascular system undergoes a series of complex, highly regulated series of events involving differentiation, migration and association of primitive endothelial cells. This process is termed vasculogenesis. A further remodeling of the primitive vascular system forms the mature cardiovascular system. This process is known as angiogenesis (sprouting of new capillary vessels from pre-existing vasculature). Study of tumor angiogenesis has led to the identification of several proteins including basic fibroblast growth factor (bFGF) and vascular endothelial growth factor. VEGF acts by interacting with a family of largely endothelial-specific receptor tyrosine kinases that includes VEGFR-1 (flt-1/flk-2), VEGFR-2 (flk- 1/KDR), and VEGFR-3/Flt-4. Disruption of VEGFRs interferes with differentiation of endothelial cells and it is lethal for the embryo. FLT-4 (mouse 1363aa and human 1298aa), a receptor protein tyrosine kinase, is a receptor for VEGF-C. Mouse FLT-4 protein topology: 1-24aa signal peptide, 25-1363 mature protein (25-775 EC domain, 776-797aa TM domain, 798-1363aa CP domain). FLT-4 is type 1 membrane protein. It is expressed in adult lung, and liver, and in fetal liver, brain, intestine, and placenta. Applications: Suitable for use in Western Blot, ELISA. Other applications not tested. Recommended Dilution: Western Blot: 1-10ug/ml (Chemiluminescence) ELISA: 1:10,000-1:100,000, 50-100ng of control peptide/well Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile ddH2O or PBS. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Isotype: IgG1
• Purity: Purified by immunoaffinity chromatography.
• Form: Supplied as a lyophilized powder from PBS, 0.05% sodium azide.