VHL, CT (Von Hippel-Lindau Disease Tumor Suppressor, pVHL, Protein G7), Rabbit
Catalog Number:
USB-V2640-03J
- Images (0)
| Article Name: | VHL, CT (Von Hippel-Lindau Disease Tumor Suppressor, pVHL, Protein G7), Rabbit |
| Biozol Catalog Number: | USB-V2640-03J |
| Supplier Catalog Number: | V2640-03J |
| Alternative Catalog Number: | USB-V2640-03J-200 |
| Manufacturer: | US Biological |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | ELISA, WB |
| Immunogen: | Synthetic peptide selected from the C-terminal region of human VHL (KLH). |
| Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of VHL gene is the basis of familial inheritance of VHL syndrome. The protein is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:50-1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
Product Guarantee and Expert Support
