VHL (Von Hippel-Lindau Disease Tumor Suppressor, Protein G7, pVHL), Goat
Catalog Number:
USB-V2640-04C
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| Article Name: | VHL (Von Hippel-Lindau Disease Tumor Suppressor, Protein G7, pVHL), Goat |
| Biozol Catalog Number: | USB-V2640-04C |
| Supplier Catalog Number: | V2640-04C |
| Alternative Catalog Number: | USB-V2640-04C-100 |
| Manufacturer: | US Biological |
| Host: | Goat |
| Category: | Antikörper |
| Application: | ELISA, WB |
| Immunogen: | Synthetic peptide corresponding to C-RSLVKPENYRRLD at the internal region of human VHL. |
| Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of VHL gene is the basis of familial inheritance of VHL syndrome. The protein is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:128,000 Western Blot: 0.01-0.03ug/ml, observed in human ovary and testis lysates and also in lysates of mouse and rat testis, brain and of all human and mouse cell lines tested on ~17kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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