Von Hippel-Lindau Protein, aa1-154, beta Domain, Recombinant, Human, His-Tag (vHL)
Biozol Catalog Number:
USB-V2640-15
Supplier Catalog Number:
V2640-15
Alternative Catalog Number:
USB-V2640-15-250
Manufacturer:
US Biological
Category:
Molekularbiologie
Von Hippel-Lindau disease (vHL) is a dominant inherited syndrome characterized by the predisposition to develop various kinds of benign and malignant tumors, including clear cell renal carcinomas, pheochromocytomas and hemangioblastomas of the central nervous system and retina. vHL syndrome is caused by germline mutation in the vHL tumor suppressor, and vHL tumors are associated with loss or mutation of the remaining wild-type allele. vHL has two domains: a roughly 100-residue NH2-terminal domain rich in beta sheet (beta-domain) and a smaller alpha-helical domain (alpha-domain), held together by two linkers and a polar interface. vHL protein is also involved in the degradation of hypoxia-inducible factor (HIF). Molecular Weight: 19.2kD (174 amino acids) Sequence: MGSSHHHHHH SSGLVPRGSH MPRRAENWDE AEVGAEEAGV EEYGPEEDGG EESGAEESGP EESGPEELGA EEEMEAGRPR PVLRSVNSRE PSQVIFCNRS PRVVLPVWLN FDGEPQPYPT LPPGTGRRIH SYRGHLWLFR DAGTHDGLLV NQTELFVPSL NVDGQPIFAN ITLP Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight:
19.2
Purity:
Purified by conventional chromatography techniques ( 95% by SDS PAGE).
Form:
Supplied as a liquid in PBS, 2mM EDTA, 1mM DTT, pH 7.4.
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