Wnt3a (Wingless-type MMTV (Mouse Mammary Tumor Virus) Integration Site Family Member), Rabbit
Catalog Number:
USB-W3011-02C
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| Article Name: | Wnt3a (Wingless-type MMTV (Mouse Mammary Tumor Virus) Integration Site Family Member), Rabbit |
| Biozol Catalog Number: | USB-W3011-02C |
| Supplier Catalog Number: | W3011-02C |
| Alternative Catalog Number: | USB-W3011-02C-100 |
| Manufacturer: | US Biological |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | WB |
| Immunogen: | Synthetic peptide corresponding to residues surrounding Asp294 of human Wnt3a. Species sequence homology: human (100%) Epitope: Central |
| The Wnt family includes several secreted glycoproteins that play important roles in animal development (1). There are 19 Wnt genes in the human genome that encode functionally distinct Wnt proteins (2). Wnt members bind to the Frizzled family of seven-pass transmembrane proteins and activate several signaling pathways (3). The canonical Wnt/beta-catenin pathway also requires a coreceptor from the low-density lipoprotein receptor family (4). Aberrant activation of Wnt signaling pathways is involved in several types of cancers (5). Wnt3a protein is palmitoylated and can function as a growth factor for hematopoietic stem cells (6). Although functionally distinct, Wnt3a shows high homology to Wnt3 (7). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot (transfected): 1:1000. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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