WWOX (WWOX, WW domain containing oxidoreductase, FOR, FRA16D, HHCMA56, PRO0128, WWOX v8, FOR II protein, WW domain-containing oxidoreductase, WW domain-containing protein WWOX, fragile 16D oxido reductase, fragile site FRA16D oxid
Biozol Catalog Number:
USB-W9100-10
Supplier Catalog Number:
W9100-10
Alternative Catalog Number:
USB-W9100-10-100
Manufacturer:
US Biological
Host:
Rabbit
Category:
Antikörper
Application:
IHC, WB
Immunogen:
Peptide representing residues 89-107 RLAFTVDDNPTKPTTRQRY of WWOX.
WW domain-containing oxidoreductase WWOX, also known as WOX1 or FOR, is a proapoptotic protein and a tumor suppressor gene. Because mutation or deletion in the coding region of WWOX is rarely found, it is speculated that the appearance of aberrant transcripts affects progression of many cancers. In addition, protein levels of WWOX, its Tyr33-phosphorylated form, and WOX2 are significantly down-regulated in the neurons of Alzheimers hippocampi. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:1000-1:5000 Optimal dilutions to be determined by the researcher. Note: Investigators occasionally observe in overdeveloped blots a faint upper ladder-like banding pattern in many cell types using WWOX1 antibodies against Tyr33 phosphorylation. It is surmised that faint upper bands may represent WWOX ubiquitination. However these bands do not appear if properly developed. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Purity:
Purified by immunoaffinity chromatography.
Form:
Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
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