XRCC3 (DNA Replication, Repair and Recombination Factor), Rabbit
Biozol Catalog Number:
USB-X9503-01
Supplier Catalog Number:
X9503-01
Alternative Catalog Number:
USB-X9503-01-100
Manufacturer:
US Biological
Host:
Rabbit
Category:
Antikörper
Application:
WB
Immunogen:
A synthetic partial peptide of human XRCC3.
Five human RAD51 homologs have been identified: XRCC2, XRCC3, RAD51B, RAD51C, and RAD51D. Each of these homolgs interacts with one or more of the others, with all of the proteins involved in one complex or multiple smaller complexes. XRCC3 (x-ray cross complementing) was first identified as a human gene complementing the DNA damage sensitivity, chromosonal instability and impaired growth of the mutant hamster cell line irs1SF. This fact coupled with XRCC3 being a member of the RAD51 gene family have implied a role in the repair of DNA damage by homologous recombination. By Western blot, this antibody recognizes a band at 38kDa, representing XRCC3. There are multiple bands for TK6 and HeLa cell extracts (this is normal and seen with XRCC3 recombinant protein). The band just above the XRCC3 band does not appear in nuclear extracts. Suggested Working Diultions: Western Blot-1:5,000 (ECL, using 100 ug Hela lysate) Positive control: TK6 lysates and HeLa lysates, whole cell)
Purity:
Purified by affinity chromatography.
Form:
Supplied as a liquid in PBS, pH 7.2, 0.05% sodium azide.
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