ZBTB2 (Zinc Finger and BTB Domain-containing Protein 2, KIAA1483, ZNF437), Rabbit
Biozol Catalog Number:
USB-Z0330-25
Supplier Catalog Number:
Z0330-25
Alternative Catalog Number:
USB-Z0330-25-100
Manufacturer:
US Biological
Host:
Rabbit
Category:
Antikörper
Application:
IHC, WB
Immunogen:
Synthetic peptide corresponding to aa450 to 500 of human ZBTB2.
ZBTB2 is a member of the POK (POZ domain Krüppel-like zinc finger) family and plays an important role in cell cycle regulation. It is a transcription factor and a potent repressor of the ARF-HDM2-p53-p21 pathway. ZBTB2 represses the transcription of the p21, p53 and ARF genes and activates HDM2 gene. ZBTB2 and Sp1 compete with each other in binding to the GC-box 5:6 elements and the two p53 binding elements. ZBTB2 directly interacted with p53 via its zinc fingers, inhibiting p53 binding and repressing transcription activation by p53. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 2-5ug/ml Immunohistochemistry (formalin fixed paraffin embedded): 5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
