ZNF198 (Zinc Finger MYM-type Protein 2, Fused in Myeloproliferative Disorders Protein, Rearranged in Atypical Myeloproliferative Disorder Protein, Zinc Finger Protein 198, ZMYM2, FIM, RAMP), Rabbit
Catalog Number:
USB-Z0741-40E
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| Article Name: | ZNF198 (Zinc Finger MYM-type Protein 2, Fused in Myeloproliferative Disorders Protein, Rearranged in Atypical Myeloproliferative Disorder Protein, Zinc Finger Protein 198, ZMYM2, FIM, RAMP), Rabbit |
| Biozol Catalog Number: | USB-Z0741-40E |
| Supplier Catalog Number: | Z0741-40E |
| Alternative Catalog Number: | USB-Z0741-40E-100 |
| Manufacturer: | US Biological |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | IHC, WB |
| Immunogen: | Synthetic peptide corresponding to aa1250-1300 of human Zinc finger protein 198. |
| ZNF198 is a ubiquitously expressed nuclear protein whose physiological role is largely unknown. It consists of 5 N-terminal zinc finger motifs responsible for protein-protein interactions, a central proline-rich domain and C-terminal nuclear localization signal (NLS) and an acidic domain. Reciprocal chromosomal translocation involving ZNF198 and FGFR1 results in the formation of ZNF198/FGFR1 fusion kinase protein. This fusion protein is a ligand-dependent, constitutively active cytoplasmic tyrosine kinase and regulates several STAT transcription factors including STAT 1, 3 and 5. This fusion protein is an oncogenic protein and is associated with an atypical myeloproliferative disease, peripheral blood eosinophilia and T-cell leukemia/lymphoma. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.1-1ug/ml Immunohistochemistry (paraffin): 10ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Mouse skeletal muscle lysate Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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