Synthetic Zonulin peptide, corresponding to aa8-15 GGVLVQPG, conjugated to KLH.
Zonulin is a protein that participates in tight junctions between cells of the wall of the digestive tract. Initially discovered in 2000 as the target of zonula occludens toxin, secreted by cholera pathogen Vibrio cholerae. It has been implicated in the pathogenesis of celiac disease and diabetes mellitus type 1. It is being studied as a target for vaccine adjuvants. ALBA Therapeutics is developing a zonulin receptor antagonist, AT-1001, that is currently in phase 2 clinical trials. Applications: Suitable for use in ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilutions: ELISA: 1:1000 Immunohistochemistry: Frozen sections Immunohistochemistry (Paraffin): 1:300 Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Purity:
Serum.
Form:
Supplied as a lyophilized powder. Reconstitute with 20ul or 100ul sterile ddH2O.
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