G protein-coupled receptor kinase 5 Adenovirus (Ad-GRK5)
Catalog Number:
VBL-1493
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| Article Name: | G protein-coupled receptor kinase 5 Adenovirus (Ad-GRK5) |
| Biozol Catalog Number: | VBL-1493 |
| Supplier Catalog Number: | 1493 |
| Alternative Catalog Number: | VBL-1493 |
| Manufacturer: | Vector Biolabs |
| Category: | Proteine/Peptide |
| Alternative Names: | G protein-coupled receptor kinase 5 Adenovirus |
| Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonist-mediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first is the second messenger regulated kinases such as cAMP dependent protein kinase A and protein kinase C. The second is the G protein-coupled receptor kinases (GRKs). Six members of the GRK family have been identified to date. These include rhodopsin kinase (GRK 1), two forms of beta-adrenergic receptor kinase (GRK 2 or beta-ARK 1 and GRK 3 or beta-ARK 2), IT-11 (GRK 4), GRK 5 and GRK 6. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state. |
| Concentration: | 1x10 10 PFU/ml |
| Buffer: | DMEM, 2% BSA, 2.5% Glycerol |
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